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This study is a great example of the anabolic effect ostarine has on the body: Ostarine treatment resulted in a dose dependent increase in total LBM, with an increase of 1.0 kg of adipose tissue (P less than .01). Moreover, testosterone therapy increased the amount of LBM by 0.7 kg (P less than 0.01). In addition, as is characteristic of testosterone therapy, the total testosterone concentration increased with ostarine treatment by 7% (P less than 0.05) and 8% (P less than 0.05), respectively. This increase also correlated with the increase in the free testosterone concentration (R = 0.67) and decreased cortisol levels (R = −0.44)  . We also determined the time of onset of ostarsine action. For the time to onset we took into account the change in body weight (t), but for the rate of onset we treated the subjects at the beginning of the treatment session. The time to effect onset was 2.7 months from the end of ostarine treatment or 6 months in the presence of testosterone. For the time period of ostarine treatment, we calculated the difference in body weight between these two groups as: t/Fm = F1 * F2 /F3 and thus: F1 /F2 = F1.8 /F2. Thus, the time to effect onset in the ostarine group (2.7 months and 6 months) was approximately 25% longer than the time to effect onset in the testosterone group (2.0 months and 6 months). The two groups of subjects had a great deal in common. Both were males between the ages of 18 and 28 years, although the subjects were from different ethnic groups. The number of subjects in this study was very large (180) and, to maximize the power, it was necessary to use a double-blind placebo-controlled trial. The aim of this study was to evaluate the efficacy and tolerability of ostarine in male-to-female transsexuals. The study was performed in accordance with the Helsinki Declaration as well as with the rules of the Declaration for the Protection of Human Subjects in Ethical Research conducted by the Declaration Research Network. The protocol was approved by the Ethical Committee at the School of Human Biology at the University of Leuven and by the Regional Ethics Committee in the Province of Brussels. We enrolled 180 male-to-female (MTF) and female-to-male (FTM) transsexual subjects, who met the following criterion: they were between 18 and 28 years of age, had a body mass index (BMI) ≥ Similar articles: